Hypericum perforatum




Family Hypericaceae (alt. Guttiferae)
Scientific name Hypericum perforatum L.
Synonyms Hypericum ciliatum Desrousseaux; Hypericum ciliatum Desrousseaux var. acutifolium Choisy; Hypericum commutatum Nolte; Hypericum foliosissimum Koidzumi; Hypericum lineolatum Jordan; Hypericum microphyllum Jordan; Hypericum nachitschevanicum Grossheim; Hypericum noëanum Boissier; Hypericum officinale Gaterau ex. Steudel; Hypericum officinarum Crantz; Hypericum perforatum L. subsp. chinense N. Robson; Hypericum perforatum L. subsp. lineolatum (Jordan) Berher; Hypericum perforatum L. subsp. microphyllum (Jordan) O. Debeaux; Hypericum perforatum L. subsp. veronense (Schrank) Cesati; Hypericum perforatum L. subsp. vulgare (Schimper & Spenner) A. Fröhlich; Hypericum perforatum L. var. angustifolium auct., non de Candolle; Hypericum perforatum L. var. confertiflorum Debeaux; Hypericum perforatum L. var. latifolium Koch; Hypericum perforatum L. var. mediterraneum Rouy & Foucaud; Hypericum perforatum L. var. microphyllum H. Léveillé, non de Candolle; Hypericum perforatum L. var. veronense (Schrank) Nyman; Hypericum plasonii Formánek; Hypericum stenophyllum Opiz; Hypericum veronense Schrank; Hypericum vulgare Necker; Hypericum vulgare Bauhin
Common name (Japanese common name) seiyou otogiri (セイヨウオトギリ, 西洋弟切 [meaning: European otogiri-sou (otogiri-sou = Hypericum erectum Thunberg)], kogome-ba orogiri [tiny leaved otogiri])
(English common name) common St. Johnswort, Klamath weed
Distribution (Japan) Hokkaido, Honshu, Shikoku, Kyushu
(Other nations) [native] Europe (worldwide naturalized)
Habitat Field, forest edge
Chromosomal number 2n=16, 32, 36, 48
Description Plants electing 10-100cm tall. Leaves 5-35mm long. Flowers yellow ca. 18-22mm, flowering in June to August. Perennial plants.
Reference Hypericum perforatum L.
Hypericum perforatum Linnaeus
Hypericum perforatum
Hypericum perforatum L.
Hypericum perforatum L.
Compositions for the post-treatment of seborrheal, acneiform processes and a process for the preparation thereof (US Patent 4614652/1986)
Medicinal vegetable composition for treating some hepatic and biliary diseases (US Patent 4704281/1987)
Antiviral compositions (US Patent 4898891/1990)
Antiviral aerosol compositions and pressurized containers containing same (US Patent 5049589/1991)
Medicinal agent and method for treatment of mastitis in animals and humans (US Patent 5061491/1991)
Pharmaceutical compositions having antiviral activity against human cytomegalovirus (US Patent 5316768/1994)
Methods and polycyclic aromatic compound containing compositions for treating T-cell-mediated diseases (US Patent 5514714/1996)
Method for controlling weight with hypericum perforatum and garcinia cambogia (US Patent 5911992/1999)
Compounds and therapy for resisting memory loss in humans (US Patent 6159986/2000)
Polymorphic form of a tachykinin receptor antagonist (US Patent 6096742/2000)
Use of essential oils to increase bioavailability of orally administered pharmaceutical compounds (US Patent 6121234/2000)
Pharmaceutical grade St. John's Wort (US Patent 6113907/2000)
Compositions containing in particular, riboflavin, for the local prevention of diseases of the genital and rectal mucus membranes (US Patent 6020333/2000)
Stable extract of hypericum perforatum L., a method for producing the same, and corresponding pharmaceutical preparations (US Patent 6241988/2001)
Use of hyperforin and hyperforin-containing extracts in the treatment of dementia diseases (US Patent 6322824/2001)
Methods for making Hypericum fractions and St. John's Wort products (US Patent 6291241/2001)
Treatment of herpes infection with composition containing quaternary ammonium compound and an anti-viral agent (US Patent 6284289/2001)
Compositions and methods for regulating metabolism and balancing body weight (US Patent 6399089/2002)
Method and system for providing real-time, in situ biomanufacturing process monitoring and control in response to IR spectroscopy (US Patent 6395538/2002)
Pharmaceutical with predetermined activity profile (US Patent 6458384/2002)
Herbal composition as a substitute for tobacco (US Patent 6497234/2002)
Apparatus for screening compound libraries (US Patent 6387257/2002)
Hyperforin derivatives, use thereof and formulations containing them (US Patent 6656510/2003)
Products for body hygiene based on lapacho extracts containing quercitine, their preparation and use (US Patent 6656485/2003)
Toilet training article containing an astringent agent (US Patent 6657100/2003)
Delivery of Hypericum perforatum (St. John's Wort) in tablet form (US Patent 6607754/2003)
Polymorphic form of a tachykinin receptor antagonist (US Patent 6583142/2003)
Hypericum perforatum l. oleoresin, procedure for obtaining it and uses of it (US Patent 6699512/2004)
Pharmaceutical compositions having antiviral activity against human cytomegalovirus (US Patent 6686393/2004)
Percutaneous administration preparations (US Patent 6827944/2004)
Preventive or therapeutic agent for pollen allergy, allergic rhinitis, atopic dermatitis, asthma or urticaria, or health food for prevention or improvement or reduction of symptoms thereof (US Patent 6811796/2004)
Process for quality control and standardization of medicinal plant products (US Patent 6806090/2004)
Apocynum venetum extract for use as antidepressant (US Patent 6737085/2004)
Pain reliever and method of use (US Patent 6812254/2004)
Feminine care products for the delivery of therapeutic substances (US Patent 6888043/2005)
7-Oxo-DHEA compounds for treating keratinous conditions/afflictions (US Patent 6846812/2005)
Animal model for flaviviridae infection (US Patent 6878364/2005)
Cleaning compositions and their use in feminine hygiene wipes (US Patent 6844303/2005)
Therapeutic and diagnostic methods dependent on CYP2A enzymes (US Patent 6908631/2005)
Use of DHEA derivatives on keratinous substances (US Patent 6964954/2005)
Fungicidal composition containing PQDs (US Patent 6936571/2005)
Natural formulation for the treatment and prevention of depression, containing St. John's Wort and derivatives of dihydro- and tetrahydrofolic acid (US Patent 7014865/2006)
Hyperforin halogenated derivatives, the use thereof and formulations containing them (US Patent 7057078/2006)
Hyperforin derivatives, the use thereof and formulations containing them (US Patent 7105705/2006)
Preparation for oral administration (US Patent 7135198/2006)
Arylpiperazinyl compounds (US Patent 7153858/2006)
Micronized vitamin C formulation (US Patent 7101563/2006)
Micropropagation and production of phytopharmaceutical plants (US Patent 7005298/2006)
Polycosanols from Ericerus pela wax (US Patent 6984666/2006)
Stable extract from Hypericum perforatum L., method for the production thereof and its use as a topical medicament (US Patent 7166310/2007)
Hypericin and hypericum extract: specific T-type calcium channel blocker, and their use as T-type calcium channel targeted therapeutics (US Patent 7195783/2007)
Methods of treating Alzheimer's disease and other amyloidoses using Hypericum perforatum and derivatives thereof (US Patent 7205008/2007)
Homeopathic formulations useful for treating pain and/or inflammation (US Patent 7229648/2007)
Cosmetic and cosmeceutical compositions for restoration of skin barrier function (US Patent 7300649/2007)
Hyperforin as cytostatic agent and hyperforin ointment or cream as application form (US Patent 7179495/2007)
Cosmetic or healing gel for application to the human skin (US Patent 7276256/2007)
Formulations for topical delivery of bioactive substances and methods for their use (US Patent 7241456/2007)
Food product and process for manufacturing same (US Patent 7258879/2007)
Antiviral and antibacterial activities of extracts from eight plants (US Patent 7220437/2007)
Method and preparation for the preventing and/or treating vascular disorders and secondary disorders associated therewith (US Patent 7208180/2007)
Composition comprising wenguanguo extracts, methods for preparing same and uses thereof (US Patent 7189420/2007)
Cosmetic dermabrasion treatment system (US Patent 7179477/2007)
Preparation of hypericin bonded with poly-N-vinylamides (US Patent 7390510/2008)
Composition for treating hepatitis C (US Patent 7381435/2008)
Therapeutic and diagnostic methods dependent on CYP2A enzymes (US Patent 7371414/2008)
Topical treatment for dyshidrosis (pompholyx) and dry skin disorders (US Patent 7357950/2008)
Medicated tampon (US Patent 7341737/2008)
Antiaging cosmetic delivery systems (US Patent 7320797/2008)
Weight control composition comprising Hypericum perforatum (WIPO Patent WO/1998/056397)
Methods of treating Alzheimer's disease and other amyloidoses using Hypericum perforatum and derivetived thereof (WIPO Patent WO/2000/057707)
Note Naturalised plants.
Many Japanese authors have distinguissed Hypericum perforatum L. var. angustifolium auct., non de Candolle (Japanese common name: Kogome-ba otogiri) with Hypericum perforatum L. var. perforatum (Japanese common name: Seiyou otogiri-sou). However, I think that such identification doesn't have any good and meanfull result.
Also many people might mis-identifed the species as Hypericum perforatum L. var. angustifolium sensu de Candolle.



July 2008
at Karuizawa Botanical Garden
July 2008
at Karuizawa Botanical Garden
July 2008
at Karuizawa Botanical Garden